Dragutan, Ileana published the artcileModulation of oxidative damage by nitroxide free radicals, Formula: C11H21BF4N2O2, the publication is Free Radical Research (2007), 41(3), 303-315, database is CAplus and MEDLINE.
Piperidine nitroxides like 2,2,6,6-tetramethyl-1-piperidinyloxy (TEMPO) are persistent free radicals in non-acidic aqueous solutions and organic solvents that may have value as therapeutic agents in medicine. In biol. environments, they undergo mostly reduction to stable hydroxylamines but can also undergo oxidation to reactive oxoammonium compounds Reactions of the oxoammonium derivatives could have adverse consequences including chem. modification of vital macromols. and deleterious effects on cell signaling. An examination of their reactivity in aqueous solution has shown that oxoammonium compounds can oxidize almost any organic as well as many inorganic mols. found in biol. systems. Many of these reactions appear to be 1-electron transfers that reduce the oxoammonium to the corresponding nitroxide species, in contrast to a prevalence of 2-electron reductions of oxoammonium in organic solvents. Amino acids, alcs., aldehydes, phospholipids, hydrogen peroxide, other nitroxides, hydroxylamines, phenols, and certain transition metal ions and their complexes are among reductants of oxoammonium, causing conversion of this species to the paramagnetic nitroxide. On the other hand, thiols and oxoammonium yield products that cannot be detected by ESR even under conditions that would oxidize hydroxylamines to nitroxides. These products may include hindered secondary amines, sulfoxamides, and sulfonamides. Thiol oxidation products other than disulfides cannot be restored to thiols by common enzymic reduction pathways. Such products may also play a role in cell signaling events related to oxidative stress. Adverse consequences of the reactions of oxoammonium compounds may partially offset the putative beneficial effects of nitroxides in some therapeutic settings.
Free Radical Research published new progress about 219543-09-6. 219543-09-6 belongs to piperidines, auxiliary class Piperidine,Fluoride,Salt,Amine,Amide, name is 4-Acetamido-2,2,6,6-tetramethyl-1-oxopiperidinium Tetrafluoroborate, and the molecular formula is C11H21BF4N2O2, Formula: C11H21BF4N2O2.
Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem