Impact of green tea intake on the pharmacokinetics of celiprolol in healthy subjects was written by Sonoda, Junichiro;Ogata, Kenji;Yoshikawa, Naoki;Sato, Keizo;Ikeda, Ryuji;Shimodozono, Yoshihiro. And the article was included in International Journal of Clinical Pharmacology and Therapeutics in 2021.Formula: C32H39NO4 The following contents are mentioned in the article:
To assess the effect of green tea intake on the pharmacokinetics of the β-blocker celiprolol. In an open-label crossover study, 3 healthy subjects were given water or a green tea beverage daily for 3 days. On day 4, each subject received a single oral dose of 200 mg celiprolol with water or green tea. Serum and urinary concentrations of celiprolol were measured for up to 24 h. Green tea intake decreased the area under the serum concentration-time curve and urinary excretion of celiprolol by 98.6 and 98.0%, resp. Green tea intake might have a neg. impact on the clin. effectiveness of celiprolol. This study involved multiple reactions and reactants, such as 2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid (cas: 83799-24-0Formula: C32H39NO4).
2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid (cas: 83799-24-0) belongs to piperidine derivatives. The piperidine ring can be found not only in more than half of the currently known structures of alkaloids, but also in many natural or synthetic compounds with interesting biological activities. Some chemotherapeutic agents have piperidine moiety within their structure, foremost among them, vinblastine and raloxifene.Formula: C32H39NO4
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem