Creating Diverse Target-Binding Surfaces on FKBP12: Synthesis and Evaluation of a Rapamycin Analogue Library was written by Wu, Xiang-Hong;Wang, Li-Sheng;Han, Yao-Hua;Regan, Nicholas;Li, Pui-Kai;Villalona, Miguel A.;Hu, Xi-Che;Briesewitz, Roger;Pei, De-Hua. And the article was included in ACS Combinatorial Science in 2011.Reference of 86069-86-5 The following contents are mentioned in the article:
Cyclopeptide analogs of rapamycin and FK506 (“rapalogs”) such as I, containing a common FKBP-binding moiety and variable effector domains, are prepared in a combinatorial library by solid-phase peptide synthesis. FKBP12 binds to most of the rapamycin analogs with high affinity (Ki values in the nanomolar to low micromolar range), creating a large repertoire of composite surfaces for potential recognition of macromol. targets such as proteins. For example, I binds to FKBP with an IC50 value of 2±1 μM (IC50 value±SD), as compared to 57±2 nM for rapamycin and 220±80 nM for FK 506. This study involved multiple reactions and reactants, such as (S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid (cas: 86069-86-5Reference of 86069-86-5).
(S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid (cas: 86069-86-5) belongs to piperidine derivatives.Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Piperidine prefers a chair conformation, similar to cyclohexane. Unlike cyclohexane, piperidine has two distinguishable chair conformations: one with the N–H bond in an axial position, and the other in an equatorial position.Reference of 86069-86-5
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem