Assessing Different E3 Ligases for Small Molecule Induced Protein Ubiquitination and Degradation was written by Ottis, Philipp;Toure, Momar;Cromm, Philipp M.;Ko, Eunhwa;Gustafson, Jeffrey L.;Crews, Craig M.. And the article was included in ACS Chemical Biology in 2017.Electric Literature of C21H21NO4 The following contents are mentioned in the article:
Proteolysis Targeting Chimera (PROTAC) technol., the recruitment of E3 ubiquitin ligases to induce the degradation of a protein target, is rapidly impacting chem. biol., as well as modern drug development. Here, we explore the breadth of this approach by evaluating different E3 ubiquitin ligases engineered in their substrate binding domains to accept a recruiting ligand. Five out of six E3 ligases were found to be amenable to recruitment for target degradation Taking advantage of the tight spatio-temporal control of inducing ubiquitination on a pre-selected target in living cells, we focused on two of the engineered E3 ligases, βTRCP and parkin, to characterize their ability to induce ubiquitination in comparison with the PROTAC-recruited endogenous E3 ligases VHL and cereblon. This study involved multiple reactions and reactants, such as (S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid (cas: 86069-86-5Electric Literature of C21H21NO4).
(S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid (cas: 86069-86-5) belongs to piperidine derivatives. The piperidine structural motif is present in numerous natural alkaloids. These include piperine, which gives black pepper its spicy taste. Piperidine derivatives bearing a masked aldehyde function in the ε-position are easily transformed into quinolizidine compounds through intramolecular reductive amination.Electric Literature of C21H21NO4
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem