Adamska-Bartlomiejczyk, Anna et al. published their research in Bioorganic & Medicinal Chemistry in 2017 | CAS: 86069-86-5

Design and characterization of opioid ligands based on cycle-in-macrocycle scaffold was written by Adamska-Bartlomiejczyk, Anna;De Marco, Rossella;Gentilucci, Luca;Kluczyk, Alicja;Janecka, Anna. And the article was included in Bioorganic & Medicinal Chemistry in 2017.Computed Properties of C21H21NO4 The following contents are mentioned in the article:

The study reports on a series of novel cyclopeptides based on the structure Tyr-[D-Lys-Phe-Phe-Asp]NH₂, a mixed μ- and κ-opioid receptor agonist with low nanomolar affinity, in which Phe⁴ residue was substituted by cyclic amino acids, such as Pro or its six-membered surrogates, piperidine-2-, 3- or 4-carboxylic acids (Pip, Nip and Inp, resp.). All derivatives exhibited high μ- and moderate δ-opioid receptor affinity, and almost no binding to the κ-opioid receptor. Conformational anal. suggested that the cis conformation of the peptide bond Phe³-Xaa⁴ influences receptor selectivity through the control of the position of Phe³ side chain. The results substantiate the use of the cycle-macrocyle scaffolds for fine-tuning receptor selectivity. This study involved multiple reactions and reactants, such as (S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid (cas: 86069-86-5Computed Properties of C21H21NO4).

(S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid (cas: 86069-86-5) belongs to piperidine derivatives. The piperidine moiety constitutes an important building block for the synthesis of a variety of bioactive natural products, alkaloids and other drugs. Some chemotherapeutic agents have piperidine moiety within their structure, foremost among them, vinblastine and raloxifene.Computed Properties of C21H21NO4

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem