Urticaria 12 days after COVID-19 mRNA booster vaccination was written by Wolfson, Anna R.;Freeman, Esther E.;Blumenthal, Kimberly G.. And the article was included in JAMA, the Journal of the American Medical Association in 2022.Name: 2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid The following contents are mentioned in the article:
A healthy 27-yr-old woman received a COVID-19 mRNA booster vaccine (Moderna) on Dec. 7, 2021. She had not experienced adverse effects after the first 2 vaccine doses on Jan. 17 and Feb. 5, 2021. Twelve days after the booster vaccination, she developed pruritic wheals on her face and bilateral, transient eyelid swelling. The patient’s urticaria did not resolve with standard-dose fexofenadine (180 mg daily) or with 4 times the standard dose, so montelukast(10 mg nightly) and an addition almidday dose of 360 mg fexofenadine was added. Two weeks after receiving omalizumab,her dermatographism resolved. Fexofenadine was decreased to 180 mg twice daily and continued omalizumab monthly for a total of 3 doses. She was counseled to increase her dose of non-sedating antihistamines starting 3 days prior to another COVID-19 mRNA vaccination. This study involved multiple reactions and reactants, such as 2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid (cas: 83799-24-0Name: 2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid).
2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid (cas: 83799-24-0) belongs to piperidine derivatives. The piperidine ring can be found not only in more than half of the currently known structures of alkaloids, but also in many natural or synthetic compounds with interesting biological activities. Piperidine derivatives are being utilized in different ways as anticancer, antiviral, antimalarial, antimicrobial, antifungal, antihypertension, analgesic, anti-inflammatory, anti-Alzheimer, antipsychotic and/or anticoagulant agents.Name: 2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem