Acute generalized exanthematous pustulosis induced by pseudoephedrine in a combination tablet with fexofenadine was written by Kusutani, Nao;Nishida, Marina;Sowa-Osako, Junko;Maekawa, Naoki;Fukai, Kazuyoshi. And the article was included in International Journal of Dermatology in 2021.Related Products of 83799-24-0 The following contents are mentioned in the article:
Acute generalized exanthematous pustulosis (AGEP) is a type of severe drug adverse reaction characterized by the acute development of numerous nonfollicular sterile pustules on a background of edematous erythema. A 52-yr-old otherwise healthy woman presented with diffuse erythema that gradually worsened over 4 days after administration of the second dose of fexofenadine (FEX)/pseudoephedrine (PSE) (Dellegra) combination tablet. A skin punch biopsy from the thigh revealed multiple subcorneal pustules with mildly acanthotic and spongiotic epidermis. Skin tests for PSE itself could not be performed because it was unavailable in a suitable form. The provocation test was not planned for fear of possible severe reactions. Here we report the first case of AGEP caused by FEX/PSE combination tablet. The patient was advised to avoid not only FEX/PSE medication but also PSE-containing OTC cold remedies and Kampo formulas. This study involved multiple reactions and reactants, such as 2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid (cas: 83799-24-0Related Products of 83799-24-0).
2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid (cas: 83799-24-0) belongs to piperidine derivatives. Piperidine and its derivatives have become increasingly popular in many synthetic schemes. Some chemotherapeutic agents have piperidine moiety within their structure, foremost among them, vinblastine and raloxifene.Related Products of 83799-24-0
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem