(S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid (cas: 86069-86-5) belongs to piperidine derivatives. Piperidine is a metabolite of cadaverine, a polyamine found in the human intestine. Fluorinated piperidines are also the subject of continued interest in medicinal chemistry, for example in the synthesis of selective dipeptidyl peptidase II (DPP II) inhibitors. Piperidine derivatives are also used in solid-phase peptide synthesis (SPPS) and many degradation reactions.SDS of cas: 86069-86-5
Introduction of Pro and its analogues in the conserved P1‘ position of trypsin inhibitor SFTI-1 retains its inhibitory activity was written by Legowska, Anna;Debowski, Dawid;Lukajtis, Rafal;Sztabkowska, Emilia;Mizeria, Aneta;Brzozowski, Krzysztof;Wysocka, Magdalena;Lesner, Adam;Rolka, Krzysztof. And the article was included in Protein & Peptide Letters in 2011.SDS of cas: 86069-86-5 The following contents are mentioned in the article:
A number of monocyclic SFTI-1 analogs modified in the conserved inhibitor P1‘ position by Pro, its L-hydroxyproline (Hyp) derivative as well as mimetics with different ring size were synthesized by the solid-phase method. Replacement of Ser6 by Pro, Hyp, and a four-member ring, L-azetidine-2-carboxylic acid (Aze), retained trypsin or chymotrypsin inhibitory activity. The determined association equilibrium constants of these analogs with a cognate enzyme were about two orders of magnitude lower than those obtained for ones with conserved Ser6. In all analogs, with the exception of one, [Phe5,Aze6]SFTI-1, the P1-P1‘ reactive site remained intact. The results provide first evidence that the conserved Ser in the P1‘ position of Bowman-Birk inhibitors can be successfully replaced by an amino acid with a secondary amine group. This study involved multiple reactions and reactants, such as (S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid (cas: 86069-86-5SDS of cas: 86069-86-5).
(S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid (cas: 86069-86-5) belongs to piperidine derivatives. Piperidine is a metabolite of cadaverine, a polyamine found in the human intestine. Fluorinated piperidines are also the subject of continued interest in medicinal chemistry, for example in the synthesis of selective dipeptidyl peptidase II (DPP II) inhibitors. Piperidine derivatives are also used in solid-phase peptide synthesis (SPPS) and many degradation reactions.SDS of cas: 86069-86-5
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem