Vatansever, Erol C. et al. published their research in Proceedings of the National Academy of Sciences of the United States of America in 2021 | CAS: 83799-24-0

2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid (cas: 83799-24-0) belongs to piperidine derivatives. The piperidine moiety constitutes an important building block for the synthesis of a variety of bioactive natural products, alkaloids and other drugs. Piperidine derivatives bearing a masked aldehyde function in the ε-position are easily transformed into quinolizidine compounds through intramolecular reductive amination.Electric Literature of C32H39NO4

Bepridil is potent against SARS-CoV-2 in vitro was written by Vatansever, Erol C.;Yang, Kai S.;Drelich, Aleksandra K.;Kratch, Kaci C.;Cho, Chia-Chuan;Kempaiah, Kempaiah Rayavara;Hsu, Jason C.;Mellott, Drake M.;Xu, Shiqing;Tseng, Chien-Te K.;Liu, Wenshe Ray. And the article was included in Proceedings of the National Academy of Sciences of the United States of America in 2021.Electric Literature of C32H39NO4 The following contents are mentioned in the article:

Guided by a computational docking anal., about 30 Food and Drug Administration/European Medicines Agency (FDA/EMA)-approved small-mol. medicines were characterized on their inhibition of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease (Mpro). Of these small mols. tested, six displayed a concentration that inhibits response by 50% (IC50) value below 100μM in inhibiting Mpro, and, importantly, three, i.e., pimozide, ebastine, and bepridil, are basic mols. that potentiate dual functions by both raising endosomal pH to interfere with SARS-CoV-2 entry into the human cell host and inhibiting Mpro in infected cells. A live virus-based modified microneutralization assay revealed that bepridil possesses significant anti-SARS-CoV-2 activity in both Vero E6 and A459/ACE2 cells in a dose-dependent manner with low micromolar effective concentration, 50% (EC50) values. Therefore, the current study urges serious considerations of using bepridil in COVID-19 clin. tests. This study involved multiple reactions and reactants, such as 2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid (cas: 83799-24-0Electric Literature of C32H39NO4).

2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid (cas: 83799-24-0) belongs to piperidine derivatives. The piperidine moiety constitutes an important building block for the synthesis of a variety of bioactive natural products, alkaloids and other drugs. Piperidine derivatives bearing a masked aldehyde function in the ε-position are easily transformed into quinolizidine compounds through intramolecular reductive amination.Electric Literature of C32H39NO4

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem