Synthesis of methyl 1-(3,4-dichlorobenzyl)hexahydro-2,3-dioxo-4-pyridinecarboxylate was written by Schwan, Thomas J.;Gray, Joseph E.;Wright, George C.. And the article was included in Journal of Pharmaceutical Sciences in 1979.Safety of Ethyl 2,3-dioxopiperidine-4-carboxylate The following contents are mentioned in the article:
Me 1-(3,4-dichlorbenzyl)hexahydro-2,3-dioxo-4-pyridinecarboxylate (I) was prepared by alkylation of Me hexahydro-2,3-dioxo-4-pyridinecarboxylate with α,3,4-trichlorotoluene. I was active against pathogenic yeast species, some dermatophytic fungi and Aspergillus niger. This study involved multiple reactions and reactants, such as Ethyl 2,3-dioxopiperidine-4-carboxylate (cas: 30727-21-0Safety of Ethyl 2,3-dioxopiperidine-4-carboxylate).
Ethyl 2,3-dioxopiperidine-4-carboxylate (cas: 30727-21-0) belongs to piperidine derivatives.Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Several piperidine alkaloids isolated from natural herbs, were found to exhibit antiproliferation and antimetastatic effects on various types of cancers both in vitro and in vivo for example Piperine, Evodiamine, Matrine, Berberine and Tetrandine.Safety of Ethyl 2,3-dioxopiperidine-4-carboxylate
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem