Synthesis of Bioactive 2-Aza-Analogues of Ipecac and Alangium Alkaloids was written by Koelzer, Michael;Weitzel, Kerstin;Goeringer, H. Ulrich;Thines, Eckhard;Opatz, Till. And the article was included in ChemMedChem in 2010.Name: (S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid The following contents are mentioned in the article:
A short and versatile synthesis of functional emetine mimetics is described. The 2-aza analogs, e.g. show the characteristic structure-activity relationships of the natural series. Although they are less active than their natural counterparts, mimetic I shows an improved potency/toxicity ratio compared withe the benchmark compound emetine. This study involved multiple reactions and reactants, such as (S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid (cas: 86069-86-5Name: (S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid).
(S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid (cas: 86069-86-5) belongs to piperidine derivatives. Piperidine is a metabolite of cadaverine, a polyamine found in the human intestine. Several piperidine alkaloids isolated from natural herbs, were found to exhibit antiproliferation and antimetastatic effects on various types of cancers both in vitro and in vivo for example Piperine, Evodiamine, Matrine, Berberine and Tetrandine.Name: (S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem