Synthesis of Bioactive 2-Aza-Analogues of Ipecac and Alangium Alkaloids was written by Koelzer, Michael;Weitzel, Kerstin;Goeringer, H. Ulrich;Thines, Eckhard;Opatz, Till. And the article was included in ChemMedChem in 2010.Synthetic Route of C21H21NO4 The following contents are mentioned in the article:
A short and versatile synthesis of functional emetine mimetics is described. The 2-aza analogs, e.g. show the characteristic structure-activity relationships of the natural series. Although they are less active than their natural counterparts, mimetic I shows an improved potency/toxicity ratio compared withe the benchmark compound emetine. This study involved multiple reactions and reactants, such as (S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid (cas: 86069-86-5Synthetic Route of C21H21NO4).
(S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid (cas: 86069-86-5) belongs to piperidine derivatives.Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Fluorinated piperidines are also the subject of continued interest in medicinal chemistry, for example in the synthesis of selective dipeptidyl peptidase II (DPP II) inhibitors. Piperidine derivatives are also used in solid-phase peptide synthesis (SPPS) and many degradation reactions.Synthetic Route of C21H21NO4
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem