Design and Application of a DNA-Encoded Macrocyclic Peptide Library was written by Zhu, Zhengrong;Shaginian, Alex;Grady, LaShadric C.;O’Keeffe, Thomas;Shi, Xiangguo E.;Davie, Christopher P.;Simpson, Graham L.;Messer, Jeffrey A.;Evindar, Ghotas;Bream, Robert N.;Thansandote, Praew P.;Prentice, Naomi R.;Mason, Andrew M.;Pal, Sandeep. And the article was included in ACS Chemical Biology in 2018.COA of Formula: C21H21NO4 The following contents are mentioned in the article:
A DNA-encoded macrocyclic peptide library was designed and synthesized with 2.4 × 1012 members composed of 4-20 natural and non-natural amino acids. Affinity-based selection was performed against two therapeutic targets, VHL and RSV N protein. On the basis of selection data, some peptides were selected for resynthesis without a DNA tag, and their activity was confirmed. This study involved multiple reactions and reactants, such as (S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid (cas: 86069-86-5COA of Formula: C21H21NO4).
(S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid (cas: 86069-86-5) belongs to piperidine derivatives. The piperidine structural motif is present in numerous natural alkaloids. These include piperine, which gives black pepper its spicy taste. Some chemotherapeutic agents have piperidine moiety within their structure, foremost among them, vinblastine and raloxifene.COA of Formula: C21H21NO4
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem