Hartmann, Markus et al. published their research in Journal of Medicinal Chemistry in 2021 | CAS: 1222780-33-7

1-(1-Propionylpiperidin-4-yl)-3-(4-(trifluoromethoxy)phenyl)urea (cas: 1222780-33-7) belongs to piperidine derivatives.Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Piperidine prefers a chair conformation, similar to cyclohexane. Unlike cyclohexane, piperidine has two distinguishable chair conformations: one with the N鈥揌 bond in an axial position, and the other in an equatorial position.Category: piperidines

Combined Cardioprotective and Adipocyte Browning Effects Promoted by the Eutomer of Dual sEH/PPAR纬 Modulator was written by Hartmann, Markus;Bibli, Sofia-Iris;Tews, Daniel;Ni, Xiaomin;Kircher, Theresa;Kramer, Jan S.;Kilu, Whitney;Heering, Jan;Hernandez-Olmos, Victor;Weizel, Lilia;Scriba, Gerhard K. E.;Krait, Sulaiman;Knapp, Stefan;Chaikuad, Apirat;Merk, Daniel;Fleming, Ingrid;Fischer-Posovszky, Pamela;Proschak, Ewgenij. And the article was included in Journal of Medicinal Chemistry in 2021.Category: piperidines The following contents are mentioned in the article:

The metabolic syndrome (MetS) is a constellation of cardiovascular and metabolic symptoms involving insulin resistance, steatohepatitis, obesity, hypertension, and heart disease, and patients suffering from MetS often require polypharmaceutical treatment. PPAR纬 agonists are highly effective oral antidiabetics with great potential in MetS, which promote adipocyte browning and insulin sensitization. However, the application of PPAR纬 agonists in clinics is restricted by potential cardiovascular adverse events. We have previously demonstrated that the racemic dual sEH/PPAR纬 modulator RB394 (3) simultaneously improves all risk factors of MetS in vivo. In this study, we identify and characterize (R)-3 (I), the eutomer of 3. We provide structural rationale for mol. recognition of the eutomer. Furthermore, we could show that the dual sEH/PPAR纬 modulator is able to promote adipocyte browning and simultaneously exhibits cardioprotective activity which underlines its exciting potential in treatment of MetS. This study involved multiple reactions and reactants, such as 1-(1-Propionylpiperidin-4-yl)-3-(4-(trifluoromethoxy)phenyl)urea (cas: 1222780-33-7Category: piperidines).

1-(1-Propionylpiperidin-4-yl)-3-(4-(trifluoromethoxy)phenyl)urea (cas: 1222780-33-7) belongs to piperidine derivatives.Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Piperidine prefers a chair conformation, similar to cyclohexane. Unlike cyclohexane, piperidine has two distinguishable chair conformations: one with the N鈥揌 bond in an axial position, and the other in an equatorial position.Category: piperidines

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem