With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.106-52-5,1-Methylpiperidin-4-ol,as a common compound, the synthetic route is as follows.
Compound 1-methyl-4-piperidinol (1.26 g, 11 mmol) and NaH (240 mg, 12 mmol), were added into a round-bottom flask using DMF as a solvent. The mixture was stirred in ice water bath for 30 min, and 2-fluoro-5-nitrotrifluorotoluene (2.09 g , 10 mmol) was added, and the reaction was carried out at room temperature for 12 hours. The product 1-methyl-4-(4-nitro-2-(trifluoromethyl)phenylhydroxy)piperidine (2.9 g, yield: 95%) was obtained by purification.
The synthetic route of 106-52-5 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Shanghai Institute of Materia Medica, Chinese Academy of Sciences; HU, Youhong; GENG, Meiyu; REN, Wenming; DING, Jian; GUAN, Xiaocong; AI, Jing; WANG, Lang; PENG, Xia; LIU, Yang; DAI, Yang; ZENG, Limin; (45 pag.)EP3584239; (2019); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem