Pharmacoeconomic evaluation of levocetrizine, monteleukast and fexofenadine in allergic rhinitis in Jharkhand, India was written by Kumar, Pramveer;Chandra, Satish;Kumari, Kusum;Priyanki;Gari, Manju;Kumar, Sandeep;Ragini, Kavita. And the article was included in World Journal of Pharmacy and Pharmaceutical Sciences in 2021.Synthetic Route of C32H39NO4 The following contents are mentioned in the article:
Pharmacoeconomics has been defined as the description and anal. of the cost of drug therapy to healthcare systems and society. More specifically, it is the process of identifying, measuring, and comparing the costs, risks, and benefits of programs or therapies and determining which alternative produces the best health outcome for the resource invested. We have selected cost-effectiveness anal. in our study, because the mainadvantage of this approach is that the outcomes are easier to quantify. Allergic Rhinitis is an important public health problem., the aim of this study was to find out the less costly medication for allergic rhinitis on basis of pharmacoeconomic anal. This observational follow up study was conducted in the department of pharmacol. & Therapeutics, RIMS, Ranchi among Diagnosed cases of Allergic Rhinitis patient (persistent, moderate- severe type as per ARIA Classification), patient aged 18 to 60 years inclusive of either gender, with treatment duration of 2 wk. Drugs used were monteleukast, levocetrizine and fexofenadine. Mean changes in TNSS at the end of 24 h, 1st and 2nd week were seen to compare the effect of drugs with and without Montelukast with the help of Total Nasal Score. Cost effective anal. was done. All the study drugs have shown significant improvement in quality of life of Allergic rhinitis patients. Pharmacoeconomically, Levocetriirizine has been found the most cost effective amongst study drugs and fexofenadine is the least cost effective. This study involved multiple reactions and reactants, such as 2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid (cas: 83799-24-0Synthetic Route of C32H39NO4).
2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid (cas: 83799-24-0) belongs to piperidine derivatives.Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Industrially, piperidine is produced by the hydrogenation of pyridine, usually over a molybdenum disulfide catalyst. Pyridine can also be reduced to piperidine via a modified Birch reduction using sodium in ethanol.Synthetic Route of C32H39NO4
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem