Biotransformation of Chemicals in Water-Sediment Suspensions: Influencing Factors and Implications for Persistence Assessment was written by Seller, Carolin;Honti, Mark;Singer, Heinz;Fenner, Kathrin. And the article was included in Environmental Science & Technology Letters in 2020.Formula: C32H39NO4 The following contents are mentioned in the article:
Chems.’ half-lives derived from biotransformation simulation studies are central metrics for persistence assessment in international regulatory frameworks. To determine the persistence of chems. released to the aquatic environment, paradigm shifts in recent and ongoing revisions of chem. legislation assign increasing importance to OECD 309 simulation studies. OECD 309 studies were designed to target biotransformation in natural water (pelagic test) or in water amended with sediment (suspension test). Suspension tests bear several advantages over the pelagic test, most importantly, employing higher bacterial cell densities, which promote biotransformation of various chems. at observable rates. However, experience with suspension tests is limited. In this study, we followed the fate of 43 pharmaceuticals, pesticides, and industrial chems. in various suspension test setups and elucidated parameters influencing biotransformation kinetics and half-lives derived thereof. Besides striking intrastudy variability between replicates, we found that differences in sediment origin and bacterial cell d. resulted in chem. half-lives that were different by up to 2 orders of magnitude, making persistence classification rather uncertain. However, data suggested that test systems employing bacterial cell densities close to the upper limit of what is commonly observed in natural surface waters (i.e., 107 cells mL-1) yielded increased and more uniform biotransformation of chems. This study involved multiple reactions and reactants, such as 2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid (cas: 83799-24-0Formula: C32H39NO4).
2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid (cas: 83799-24-0) belongs to piperidine derivatives. Piperidine is a metabolite of cadaverine, a polyamine found in the human intestine. Industrially, piperidine is produced by the hydrogenation of pyridine, usually over a molybdenum disulfide catalyst. Pyridine can also be reduced to piperidine via a modified Birch reduction using sodium in ethanol.Formula: C32H39NO4
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem