Cost analysis of second generation antihistamines available in Indian market was written by Nagarajan, Gowtham;Gujjarlamudi, Hima Bindu;Nagireddy, Uma Maheswari;Kankipati, Solomon Raju. And the article was included in International Journal of Pharmacy and Pharmaceutical Research in 2022.Name: 2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid The following contents are mentioned in the article:
Antihistamine drugs are extensively used to treat allergic rhinitis and other allergies. They provide relief from nasal congestion, sneezing, or hives caused by pollen and dust mites with few side effects. Various drugs with different brands and variations in prices are available in the Indian market. This study was done to fiend out the percentage variation of cost among different brands of antihistamine drugs available in the Indian market. The cost of various second-generation antihistamine drugs available in the Indian market were referred from CIMS (current index of medical specialties) (March 2022) and Indian Drug Today (Oct. 2021 to Jan. 2022). The highest and lowest price for ten (10) tablets/capsules of each second-generation antihistamine was analyzed. The percentage cost variation and cost ratio were calculated for each drug. A total of eleven oral Second Generation Antihistamines available in the Indian market and 566 oral tablets or capsules manufactured by different companies were identified for all the Second Generation Antihistamines. Huge variation was found in the cost of different branded preparations for the same drug (40.14% for cetirizine; INR 2.06 to INR 84.76). The most expensive cetirizine was 11.39 times costlier than the least expensive cetirizine. The least-cost variation and cost ratio saw with Bepotastine (10%) and (1.1) resp. This study shows tremendous variation in the prices of antihistamine drugs, especially among second-generation antihistamine drugs available in India. Physicians have to select cost-effective drugs to decrease the economic burden on society. This study involved multiple reactions and reactants, such as 2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid (cas: 83799-24-0Name: 2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid).
2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid (cas: 83799-24-0) belongs to piperidine derivatives. The piperidine moiety constitutes an important building block for the synthesis of a variety of bioactive natural products, alkaloids and other drugs. Industrially, piperidine is produced by the hydrogenation of pyridine, usually over a molybdenum disulfide catalyst. Pyridine can also be reduced to piperidine via a modified Birch reduction using sodium in ethanol.Name: 2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem