Annatto hypersensitivity after oral ingestion confirmed by placebo-controlled oral challenge was written by Sadowska, Beata;Sztormowska, Marlena;Chelminska, Marta. And the article was included in Annals of Allergy, Asthma, & Immunology in 2021.Quality Control of 2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid The following contents are mentioned in the article:
Natural dyes, in contrast to synthetic ones, can be a source of protein, so their consumption may be associated with IgE (IgE)-dependent allergic reactions. Among natural dyes, symptoms were most often observed after carmine ingestion and only occasionally after annatto and concerned the skin, respiratory system, or even anaphylaxis. Annatto (E-160b) is a natural yellow-orange dye obtained from the seeds of the tropical tree Bixa orellana coming from the Americas. It is found as a colorant in many foods, such as cheese, margarine, breakfast cereals, grilled chicken, dressings, coffee creamers, mustard, colored rice, popcorn, ice cream, crackers, yogurts, cakes, jelly, and medicines. Here, we report the first case of annatto hypersensitivity in the form of contact urticaria and oral ingestion. A 34-yr-old woman was hospitalized owing to recurrent urticaria for 3 years who was treated for asthma and hypothyroidism and underwent tonsillectomy, cesarean section, and Helicobacter pylori eradication. The urticaria wheals were usu- ally generalized, except for those in the hands and genital areas, occurredupto4timesayear,lastedfor3days,andusually resolved with a triple daily dose of fexofenadine. The small number of annatto hypersensitivity reports may be due to insufficient awareness of the possible allergy to natural dyes. The growing tendency to replace synthetic dyes with natural dyes may result in a higher percentage of allergies in the future, because their sources are plant (eg, annatto) or animal (carmine) allergens. In summary, annatto may act as an allergen or a hapten, mediating IgE-mediated allergic reactions, or alternatively as an IgE-independent mast cell activation mechanism. This study involved multiple reactions and reactants, such as 2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid (cas: 83799-24-0Quality Control of 2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid).
2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid (cas: 83799-24-0) belongs to piperidine derivatives. Piperidine is a metabolite of cadaverine, a polyamine found in the human intestine. Piperidine derivatives bearing a masked aldehyde function in the ε-position are easily transformed into quinolizidine compounds through intramolecular reductive amination.Quality Control of 2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem