Xu, Rongsong’s team published research in Carbohydrate Research in 343 | CAS: 4972-31-0

Xu, Rongsong published the artcileSynthesis of β-(1â†?)-oligo-D-mannuronic acid neoglycolipids, COA of Formula: C11H15NOS, the publication is Carbohydrate Research (2008), 343(1), 7-17, database is CAplus and MEDLINE.

Mammalian Toll-like receptors (TLRs) play important roles in host immune defense. The activation of TLR and down-stream signaling pathways have great impact on human physiol. Chem. diverse microbial products as well as synthetic ligands serve as agonists for these receptors. Recently, synthetic TLR ligands are being exploited as useful therapeutic agents for a variety of diseases including infections, inflammatory diseases, and cancers. Alginate polymers and oligosaccharides are strong immune stimulants mediated by TLR2/4, but synthesis of alginate oligomers is rarely studied. Reported here are the design and chem. synthesis of two β-(1â†?)-di- and β-(1â†?)-tri-D-mannuronic acid neoglycolipids I (n = 0, 1) as potential TLR ligands. By using 4,6-di-O-benzylidene-protected 1-thio mannoside as a glycosyl donor, the diastereoselective β-D-mannosylation protocol provides the β-(1â†?)-D-mannobiose and β-(1â†?)-D-mannotriose derivatives, which upon regioselective oxidation with TEMPO/[bis(acetoxy)iodo]benzene (BAIB) oxidation system yield the corresponding β-(1â†?)-D-mannuronic acid containing neoglycolipids I (n = 0, 1).

Carbohydrate Research published new progress about 4972-31-0. 4972-31-0 belongs to piperidines, auxiliary class Piperidine,Benzene, name is 1-(Phenylsulfinyl)piperidine, and the molecular formula is C6H3ClFNO2, COA of Formula: C11H15NOS.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem