Wu, Yong-Jin published the artcileDevelopment of New Benzenesulfonamides As Potent and Selective Nav1.7 Inhibitors for the Treatment of Pain, Computed Properties of 14613-37-7, the publication is Journal of Medicinal Chemistry (2017), 60(6), 2513-2525, database is CAplus and MEDLINE.
By taking advantage of certain features in piperidine (I), the authors developed a novel series of cyclohexylamine- and piperidine-based benzenesulfonamides as potent and selective Nav1.7 inhibitors. However, 4-((((1S,4S)-4-aminocydohexyl)methyl)amino)-5-chloro-2-fluoro-N-(thiazol-2-yl)benzenesulfonamide (24), one of the early analogs, failed to reduce phase 2 flinching in the mouse formalin test even at a dose of 100 mpk PO due to insufficient DRG exposure attributed to poor membrane permeability. Two analogs with improved membrane permeability showed much increased DRG concentrations at doses of 30 mpk PO but, confoundingly, only one of these was effective in the formalin test. More data are needed to understand the disconnect between efficacy and exposure relationships.
Journal of Medicinal Chemistry published new progress about 14613-37-7. 14613-37-7 belongs to piperidines, auxiliary class Piperidine,Amine, name is (1-Methylpiperidin-3-yl)methanamine, and the molecular formula is C12H10FeO4, Computed Properties of 14613-37-7.
Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem