Faul, Margaret M.’s team published research in Bioorganic & Medicinal Chemistry Letters in 13 | CAS: 170364-89-3

Bioorganic & Medicinal Chemistry Letters published new progress about 170364-89-3. 170364-89-3 belongs to piperidines, auxiliary class Indole,Piperidine,Amide, name is tert-Butyl 4-(1H-indol-1-yl)piperidine-1-carboxylate, and the molecular formula is C18H24N2O2, Product Details of C18H24N2O2.

Faul, Margaret M. published the artcileAcyclic N-(azacycloalkyl)bisindolylmaleimides: isozyme selective inhibitors of PKCβ, Product Details of C18H24N2O2, the publication is Bioorganic & Medicinal Chemistry Letters (2003), 13(11), 1857-1859, database is CAplus and MEDLINE.

The synthesis and structure-activity relationship (SAR) trends of a new class of N-(azacycloalkyl)bisindolylmaleimides, e.g. I (R1 = CH2-pyridyl, R2 = Me, n = 2), acyclic derivatives of staurosporine, is described. I exhibits an IC50 of 40-50 nM against the human PKCβ1 and PKCβ2 isoenzymes and selectively inhibits the PKCβ isoenzymes in comparison to other PKC isoenzymes (α, γ, δ, ε, λ, and η). The series is also kinase selective for PKC in comparison to other ATP-dependent kinases. A comparison of the protein kinase C (PKC) isoenzyme and kinase activity of the series is made to the kinase inhibitor staurosporine.

Bioorganic & Medicinal Chemistry Letters published new progress about 170364-89-3. 170364-89-3 belongs to piperidines, auxiliary class Indole,Piperidine,Amide, name is tert-Butyl 4-(1H-indol-1-yl)piperidine-1-carboxylate, and the molecular formula is C18H24N2O2, Product Details of C18H24N2O2.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem