Waser, Philipp published the artcileAn RCM-Based Total Synthesis of the Antibiotic Disciformycin B, Recommanded Product: 4-Acetamido-2,2,6,6-tetramethyl-1-oxopiperidinium Tetrafluoroborate, the publication is Angewandte Chemie, International Edition (2020), 59(40), 17393-17397, database is CAplus and MEDLINE.
The total synthesis of the potent new antibiotic disciformycin B is described, which shows significant activity against methicillin- and vancomycin-resistant Staphylococcus aureus (MRSA/VRSA) strains. The synthetic route is based on macrocyclization of a tetraene substrate to the 12-membered macrolactone core by ring-closing olefin metathesis (RCM). Although macrocyclization was accompanied by concomitant cyclopentene formation by an alternative RCM pathway, conditions were established to give the macrocycle as the major product. Key steps in the construction of the Ring Closure Metathesis substrate include a highly efficient Evans syn-aldol reaction, the asym. Brown allylation of angelic aldehyde, and the stereoselective Zn(BH4)2-mediated 1,2-reduction of an enone. The synthesis was completed by late-stage dehydrative glycosylation to introduce the
Angewandte Chemie, International Edition published new progress about 219543-09-6. 219543-09-6 belongs to piperidines, auxiliary class Piperidine,Fluoride,Salt,Amine,Amide, name is 4-Acetamido-2,2,6,6-tetramethyl-1-oxopiperidinium Tetrafluoroborate, and the molecular formula is C15H21BO3, Recommanded Product: 4-Acetamido-2,2,6,6-tetramethyl-1-oxopiperidinium Tetrafluoroborate.
Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem