With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5382-16-1,4-Piperidinol,as a common compound, the synthetic route is as follows.
Step: 3A-1Synthesis of l-(4-Nitro-phen -piperidin-4-ol.Procedure:K2C03 (2.44g, 0.0177mol) followed by l-Fluoro-4-nitro-benzene (lg, 0.00708mol) was added to a stirred solution of Piperidin-4-ol (0.86g, 0.00850mol) in DMF (5ml) and stirred at RT. The resulting reaction mixture was heated at 60C. The reaction was monitored by the TLC (50% EtOAc: hexane). The reaction mixture was cooled to RT, and ice was added into it to precipitate a solid which was collected to afford 1.45g (92% yield) of l-(4- Nitro-phenyl)-piperidin-4-ol.
The synthetic route of 5382-16-1 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; AURIGENE DISCOVERY TECHNOLOGIES LIMITED; SENGUPTA, Saumitra; RAJAGOPALAN, Srinivasan; BELAVAGI, Ningaraddi; RAMACHANDRA, Muralidhara; WO2012/59932; (2012); A1;,
Piperidine – Wikipedia
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