Crider, A. Michael published the artcileSynthesis of nitrosourea derivatives of pyridine and piperidine as potential anticancer agents, HPLC of Formula: 1205-72-7, the main research area is nitrosourea piperidinyl chloroethyl; anticancer piperidinylnitrosourea.
RNHCON(NO)CH2CH2Cl (I; R = 1-benzyl-3-piperidinyl, 1-benzyl-4-piperidinyl, 1-butyl-4-piperidinyl, 1-ethyl-3-piperidinyl, 3-pyridyl) were prepared (by reaction of RNH2 with ClCH2CH2NCO followed by nitrosation of RNHCONHCH2CH2Cl) and evaluated for anticancer activity. I (R = 1-benzyl-4-piperidinyl) hydrogen maleate exhibited good activity against intracranial L1210 leukemia as well as the mouse ependymoblastoma brain tumor system. It exhibited comparable activity in the Lewis lung carcinoma system to N,N’-bis(2-chloroethyl)-N-nitrosourea. Replacement of the N-benzyl group in both the 3-piperidinyl- and 4-piperidinylnitrosoureas resulted in less active compounds in all tumor systems tested. I (R = 3-pyridyl) was inactive in the L-1210 leukemia system.
Journal of Medicinal Chemistry published new progress about Antitumor agents. 1205-72-7 belongs to class piperidines, name is 1-Benzylpiperidin-4-amine dihydrochloride, and the molecular formula is C12H20Cl2N2, HPLC of Formula: 1205-72-7.
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem