Takai, Haruki published the artcileSynthesis of 1- and 3-(1-substituted 4-piperidinyl)-1,2,3,4-tetrahydro-2-oxoquinazolines as potential antihypertensive agents, Application In Synthesis of 1205-72-7, the main research area is quinazolinylpiperidine antihypertensive adrenergic blocking preparation; piperidine quinazolinyl oxophenylethyl hydroxyphenethyl.
Piperidinylquinazolines, e.g. I [R = R1 = H, Cl, OMe; R = H, R1 = Cl, OMe; Z = O, (H, OH)] were prepared and tested for antihypertensive activity. I [Z = (H, OH)] were generally the most effective in lowering blood pressure in the spontaneous hypertensive rat model, and KF5908 [I, R = H, R1 = Cl, Z = (H, OH)] showed strong α-adrenergic blocking activity.
Chemical & Pharmaceutical Bulletin published new progress about Antihypertensives. 1205-72-7 belongs to class piperidines, name is 1-Benzylpiperidin-4-amine dihydrochloride, and the molecular formula is C12H20Cl2N2, Application In Synthesis of 1205-72-7.
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem