Hegedus, Louis S. published the artcilePhotolytic reactions of chromium aminocarbene complexes. Conversion of amides to α-amino acids, Quality Control of 1690-74-0, the main research area is chromium aminocarbene complex photochem carbonylation; amide complexation pentacarbonylchromium dianion; stereochem carbonylation chromium aminocarbene complex.
A variety of tertiary amides were converted to chromium aminocarbene complexes by reaction with Na2Cr(CO)5 and Me3SiCl. Photolysis of these carbene complexes in MeOH or Me3COH produced α-amino esters in good to excellent yields. Aminocarbene complexes containing chiral oxazolidine groups were synthesized and photolyzed in alc. to produce chiral α-amino esters in 50-93% diastereomeric excesses. Pentacarbonyl[(dibenzylaminomethyl)carbene]chromium(0) was prepared in high yield by the N-benzylation of the corresponding monobenzyl amino complex. Base-assisted alkylation of the Me group with a variety of halides followed by photolysis in MeOH produced the alkylated alanine Me ester in excellent overall yield. Other aminocarbene complexes underwent similar reactions. With chiral, optically active aminocarbene complexes, the alkylated alanine derivative was produced with high diastereoselectivity.
Journal of the American Chemical Society published new progress about Amino acid esters Role: SPN (Synthetic Preparation), PREP (Preparation). 1690-74-0 belongs to class piperidines, name is Methyl 1-methylpiperidine-2-carboxylate, and the molecular formula is C8H15NO2, Quality Control of 1690-74-0.
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem