El Oualid, Farid published the artcileA Combinatorial Approach toward the Generation of Ambiphilic Peptide-Based Inhibitors of Protein:Geranylgeranyl Transferase-1, Quality Control of 158922-07-7, the main research area is protein geranylgeranyl transferase inhibitor peptide combinatorial solid phase preparation.
A combinatorial synthesis of oligopeptide analogs and their evaluation as protein geranylgeranyl transferase inhibitors is presented. The combinatorial strategy is based on the random mutation, in each new generation, of one of any of the four amino acid building blocks of which the most effective compounds of the previous generation are assembled. In this way, a progressive improvement of the average inhibitory activity was observed until the fifth generation. The most active inhibitors were found to inhibit PGGT-1 in the low micromolar range (IC50 = 3.8-8.1 μM).
Journal of Combinatorial Chemistry published new progress about Combinatorial chemistry, solid-phase. 158922-07-7 belongs to class piperidines, name is 1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-3-carboxylic acid, and the molecular formula is C21H21NO4, Quality Control of 158922-07-7.
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem