On November 15, 2009, Burgey, Christopher S.; Potteiger, Craig M.; Deng, James Z.; Mosser, Scott D.; Salvatore, Christopher A.; Yu, Sean; Roller, Shane; Kane, Stefanie A.; Vacca, Joseph P.; Williams, Theresa M. published an article.Formula: C19H18ClN3O4 The title of the article was Optimization of azepanone calcitonin gene-related peptide (CGRP) receptor antagonists: Development of novel spiropiperidines. And the article contained the following:
Several novel spiropiperidine-based CGRP receptor antagonists have been developed that maintain good potency and have reduced potential for metabolism The experimental process involved the reaction of Benzyl 7′-chloro-2′-oxo-1′,2′-dihydrospiro[piperidine-4,4′-pyrido[2,3-d][1,3]oxazine]-1-carboxylate(cas: 883984-95-0).Formula: C19H18ClN3O4
The Article related to spiropiperidine cgrp receptor antagonist preparation migraine, Pharmacology: Structure-Activity and other aspects.Formula: C19H18ClN3O4
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem