On August 15, 2016, Etukala, Jagan R.; Zhu, Xue Y.; Eyunni, Suresh V. K.; Onyameh, Edem K.; Ofori, Edward; Bricker, Barbara A.; Kang, Hye J.; Huang, Xi-Ping; Roth, Bryan L.; Ablordeppey, Seth Y. published an article.Computed Properties of 39512-49-7 The title of the article was Development of CNS multi-receptor ligands: Modification of known D2 pharmacophores. And the article contained the following:
Several known D2 pharmacophores have been explored as templates for identifying ligands with multiple binding affinities at dopamine and serotonin receptors considered as clin. relevant receptors in the treatment of neuropsychiatric diseases. This approach has resulted in the identification of ligands that target multiple CNS receptors while avoiding others associated with deleterious effects. Three compounds including I may have potential for further development as antipsychotic agents as they favorably interact with the clin. relevant receptors including D2R, 5-HT1AR, and 5-HT7R. The authors have also identified the pair of compounds I and II as high affinity D2R ligands with and without SERT binding affinities, resp. These differential binding profiles endow the pair with the potential for evaluating SERT contributions to antipsychotic drug activity in animal behavioral models. In addition, compound I has no significant affinity for 5-HT2CR and binds only moderately to the H1R, suggesting it may not induce weight gain or sedation when used clin. Taken together, compound I displays an interesting pharmacol. profile that necessitates the evaluation of its functional and in vivo effects in animal models which are currently ongoing. The experimental process involved the reaction of 4-(4-Chlorophenyl)piperidin-4-ol(cas: 39512-49-7).Computed Properties of 39512-49-7
The Article related to central nervous system receptor ligand d2 pharmacophore antipsychotic, antipsychotic, cns receptor, dopamine receptor ligands, multi-receptor targeting, pharmacophore, Pharmacology: Structure-Activity and other aspects.Computed Properties of 39512-49-7
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Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem