On April 30, 2014, Chai, Christina L. L.; Teo, Serena L. M.; Jameson, Felicity K. M.; Lee, Serina S. C.; Likhitsup, Asawin; Chen, Chia-Lung; Rittschof, Dan published an article.Synthetic Route of 39512-49-7 The title of the article was Loperamide-based compounds as additives for biofouling management. And the article contained the following:
The com. pharmaceutical Imodium, which contains the active ingredient loperamide hydrochloride, has been shown to have biofouling control properties. However, due to concerns associated with safety and persistence of this active pharmaceutical ingredient (API) in the environment, the development of loperamide as an anti-fouling additive is not desirable. In this paper, we report our efforts directed towards the design and synthesis of small mol. anti-foulants using the loperamide parent compound as the lead compound These loperamide-based compounds can be synthesized readily and inexpensively. Several of the compounds identified are potentially useful as additives in marine antifouling coatings as they control attachment of barnacles in laboratory tests and an estimation program (BIOWIN) developed by the US Environmental Protection Agency predicts that they will degrade completely in weeks to months. The experimental process involved the reaction of 4-(4-Chlorophenyl)piperidin-4-ol(cas: 39512-49-7).Synthetic Route of 39512-49-7
The Article related to balanus loperamide additive marine antifouling coating material, Agrochemical Bioregulators: Microbial and other aspects.Synthetic Route of 39512-49-7
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem