On October 31, 2020, Neganova, Margarita E.; Klochkov, Sergey G.; Pukhov, Sergey A.; Afanasieva, Svetlana V.; Aleksandrova, Yulia R.; Yandulova, Ekaterina Y.; Avila-Rodriguez, Marco F.; Mikhaleva, Liudmila M.; Nikolenko, Vladimir N.; Somasundaram, Siva G.; Kirkland, Cecil E.; Aliev, Gjumrakch published an article.Related Products of 39512-49-7 The title of the article was Synthesis and Cytotoxic Activity of Azine Derivatives of 6-Hydroxyxanthanodiene. And the article contained the following:
Background: The conjugates of the sesquiterpene lactone of the eremophilane series of 6-hydroxyxanthanodiene with hydrogenated azines (piperidines and piperazines) have been synthesized and identified by NMR spectrometer. Objective: A lactone with an unusual skeleton “6-hydroxyxanthanodiene” was extracted from the plant Elecampane (Inula helenium L) and identified various species with NMR spectrometer. Methods: The cytotoxic, mitochondrial, and antioxidant activities on different tumor lines such as A549, HCT116, RD and Jurkat were investigated and determined possible mechanisms. Results: The results showed that the most potent compound was IIIi exhibiting highest cytotoxicity against RD cells (IC50 25.23 ± 0.04 μM), depolarized the mitochondrial membrane and was an effective antioxidant (IC50 inhibition of LP 10.68 ± 3.21 μM) without any toxic side effect on healthy cells. Conclusion: The conjugates of sesquiterpene lactone 6-hydroxyxanthanodiene III and hydrogenated azines may help to design potential promising anticancer drugs. The experimental process involved the reaction of 4-(4-Chlorophenyl)piperidin-4-ol(cas: 39512-49-7).Related Products of 39512-49-7
The Article related to hydroxyxanthanodiene azine derivative cytotoxicity anticancer drug, 6-hydroxyxanthanodiene, anticancer drug, antioxidants, apoptosis, azines, cytotoxicity, mitochondria, Placeholder for records without volume info and other aspects.Related Products of 39512-49-7
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem