On June 12, 2014, Frei, Beat; Gobbi, Luca; Grether, Uwe; Kimbara, Atsushi; Nettekoven, Matthias; Roever, Stephan; Rogers-Evans, Mark; Schulz-Gasch, Tanja published a patent.Safety of tert-Butyl 4-amino-4-(2-methoxy-2-oxoethyl)piperidine-1-carboxylate The title of the patent was Preparation of novel pyridine derivatives as cannabinoid receptor 2 agonists. And the patent contained the following:
The title compounds I [R1 = halo, cycloalkylalkoxy, alkylsulfonyl, etc.; R2 = halo, cycloalkyl, haloalkyl, etc.; R3 = (alkyl)(oxo)pyrrolidinyl or C(R4R5)C(R6R7)C(O)R8; R4, R5 = H, alkyl, Ph, etc.; or R4 and R5 together with the carbon atom to which they are attached form cycloalkyl, oxetanyl, thiethanyl, etc.; R6, R7 = H, alkyl; or one of R4 and R5 and one of R6 and R7, together with the carbon atoms to which they are attached, form cycloalkyl, and the other ones are both hydrogen at the same time; R8 = NH2, alkoxy, alkylamino, OH], useful as CB2 receptor agonists were prepared and formulated. E.g., a multi-step synthesis of the amide II, starting from Me 5-bromo-pyridine-2-carboxylate, was described. The exemplified compounds I showed an excellent affinity for the CB2 receptor with affinities below 10 μM (specific data given). The experimental process involved the reaction of tert-Butyl 4-amino-4-(2-methoxy-2-oxoethyl)piperidine-1-carboxylate(cas: 362703-57-9).Safety of tert-Butyl 4-amino-4-(2-methoxy-2-oxoethyl)piperidine-1-carboxylate
The Article related to pyridine amide preparation cannabinoid receptor 2 cb2 agonist, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Safety of tert-Butyl 4-amino-4-(2-methoxy-2-oxoethyl)piperidine-1-carboxylate
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem