On January 1, 2014, Hatae, Noriyuki; Nagayama, Tomoyuki; Esaki, Hiroyoshi; Kujime, Eiko; Minami, Masabumi; Ishikura, Minoru; Choshi, Tominari; Hibino, Satoshi; Okada, Chiaki; Toyota, Eiko; Nagasawa, Hideko; Iwamura, Tatsunori published an article.Application of 39512-49-7 The title of the article was Synthesis of 4-arylpiperidin-4-ol derivatives of loperamide as agents with potent antiproliferative effects against HCT-116 and HL-60 cells. And the article contained the following:
The synthesis of 4-arylpiperidin-4-ol derivatives of loperamide I [R1 = n-Pr, Ph2C(OH)CH2, R2 = 4-ClC6H4; R1 = Ph2C(OH)CH2CH2, R2 = Ph, 4-ClC6H4, 3-F3CC6H4] and N-(3-hydroxy-3,3-diphenylpropyl)piperidine was carried out by alkylation of the corresponding N-unsubstituted piperidines. The synthesized compounds were tested for their antiproliferative activity against HCT-116 cells and HL-60 cells. The N-substituents on 4-arylpiperidin-4-ol units were found to play an important role in their antiproliferative activity, and the N-diphenylpropanol analogs exhibited the most potent antiproliferative activity. The experimental process involved the reaction of 4-(4-Chlorophenyl)piperidin-4-ol(cas: 39512-49-7).Application of 39512-49-7
The Article related to piperidinol aryl preparation loperamide antiproliferative activity, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Application of 39512-49-7
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem