On January 11, 2018, Amata, Emanuele; Rescifina, Antonio; Prezzavento, Orazio; Arena, Emanuela; Dichiara, Maria; Pittala, Valeria; Montilla-Garcia, Angeles; Punzo, Francesco; Merino, Pedro; Cobos, Enrique J.; Marrazzo, Agostino published an article.Recommanded Product: 39512-49-7 The title of the article was (+)-Methyl (1R,2S)-2-{[4-(4-Chlorophenyl)-4-hydroxypiperidin-1-yl]methyl}-1-phenylcyclopropanecarboxylate [(+)-MR200] Derivatives as Potent and Selective Sigma Receptor Ligands: Stereochemistry and Pharmacological Properties. And the article contained the following:
Methoxycarbonyl-1-phenyl-2-cyclopropylmethyl based derivatives [cis-(+)-MR200], [cis-(-)-MR201], and [trans-(±)-MR204], have been identified as new potent sigma (σ) receptor ligands. In the present paper, novel enantiomerically pure analogs were synthesized and optimized for their σ receptor affinity and selectivity. Docking studies rationalized the results obtained in the radioligand binding assay. Absolute stereochem. was unequivocally established by X-ray anal. of a precursor as camphorsulfonyl derivative The most promising compound, I, showed remarkable selectivity over a panel of more than 15 receptors as well as good chem. and enzymic stability in human plasma. An in vivo evaluation evidenced that I, in contrast to its isomers, which behave as σ1 antagonists, exhibited a σ1 agonist profile. These data clearly demonstrated that compound I, due to its σ1 agonist activity and favorable receptor selectivity and stability, provided an useful tool for the study of σ1 receptors. The experimental process involved the reaction of 4-(4-Chlorophenyl)piperidin-4-ol(cas: 39512-49-7).Recommanded Product: 39512-49-7
The Article related to cyclopropylmethyl piperidine receptor sigma ligand neurodegenerative disorder human, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Recommanded Product: 39512-49-7
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem