On August 1, 2019, Crews, Craig M.; Burslem, George; Cromm, Philipp M.; Jaime-Figueroa, Saul; Toure, Momar published a patent.Category: piperidines The title of the patent was Preparation of imide-based compounds as modulators of proteolysis and methods of use. And the patent contained the following:
The description relates to imide-based compounds of formula I, including bifunctional compounds comprising the same, which find utility as modulators of targeted ubiquitination, especially inhibitors of a variety of polypeptides and other proteins which are degraded and/or otherwise inhibited by bifunctional compounds according to the present invention. In particular, the description provides compounds, which contain on one end a ligand which binds to the cereblon E3 ubiquitin ligase and on the other end a moiety which binds a target protein such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of that protein. Compounds can be synthesized that exhibit a broad range of pharmacol. activities consistent with the degradation/inhibition of targeted polypeptides of nearly any type. Compounds of formula I wherein L is a chem. linker: PTM is a protein target moiety that binds to at target protein or polypeptide; CLM is a cereblon E3 ubiquitin ligase binding moiety; and salts, solvates, polymorphs, and deuterated forms thereof, are claimed. Example compound II was prepared by a multistep procedure (procedure given). The invention compounds were evaluated for their protein degradation activity (data given). The experimental process involved the reaction of 2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindoline-5-carboxylic acid(cas: 1216805-11-6).Category: piperidines
The Article related to imide preparation protein degradation proteolysis modulator, Heterocyclic Compounds (More Than One Hetero Atom): Diazepines and other aspects.Category: piperidines
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem