On May 28, 2009, Gottschling, Dirk; Dahmann, Georg; Doods, Henri; Heimann, Annekatrin; Mueller, Stephan Georg; Rudolf, Klaus; Schaenzle, Gerhard; Stenkamp, Dirk published a patent.Synthetic Route of 883984-95-0 The title of the patent was Preparation of as pyridin-2-ones as CGRP receptor antagonists. And the patent contained the following:
Title compounds I and II [R1 = 2-oxoindoles with provisos; R2 = H, alkyl; R3 = H, alkylene, etc.; R4 = H, alkylenen, etc.; R5 = H, alkyl, benzyl, etc.;] and their pharmaceutically acceptable salts and formulations were prepared For example, deprotection of methoxypyridine III afforded claimed pyridinone IV. In CGRP receptor antagonists assays, compounds I and II exhibited Ki values ≤50 μM. The experimental process involved the reaction of Benzyl 7′-chloro-2′-oxo-1′,2′-dihydrospiro[piperidine-4,4′-pyrido[2,3-d][1,3]oxazine]-1-carboxylate(cas: 883984-95-0).Synthetic Route of 883984-95-0
The Article related to pyridinone preparation cgrp receptor antagonist, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Synthetic Route of 883984-95-0
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem