On September 2, 2021, Wang, Qiuwen; Guo, Yunhang; Wang, Zhiwei published a patent.Category: piperidines The title of the patent was Synthesis of pyridazine Tyk-2 inhibitors for treating inflammatory or autoimmune diseases. And the patent contained the following:
The synthesis of pyridazine heterocyclic Tyk-2 inhibitors I, wherein R1 can be H, or optionally substituted C1-6-alkyl or C3-6cycloalkyl groups; R2 can be a -C(O)- group with an (un)substituted 4-10 membered heterocyclic ring system; R3 is a fused bicyclic heterocyclic ring system with independently substituted H, halo, cyano or alkyl groups are prepared as pharmaceutically acceptable salts for treating inflammatory or autoimmune diseases. Of note, II was prepared and tested in biochem. and cellular assays with nM inhibition and high selectivity. The experimental process involved the reaction of tert-Butyl 3-(piperidin-4-yl)azetidine-1-carboxylate(cas: 1251006-64-0).Category: piperidines
The Article related to pyridazine tyk2 inhibitor preparation antiinflammatory autoimmune disease, Heterocyclic Compounds (More Than One Hetero Atom): Pyridazines, Cinnolines, and Phthalazines and other aspects.Category: piperidines
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem