Rafiq, Kiran; Saify, Zafar Saied; Kausar, Rana; Rahim, Najia; Naeem, Sabahat published an article in 2014, the title of the article was The structural modification causes the enhancement of analgesic activity of 4-(4′ chloro-phenyl)-4-hydroxy piperidine.Quality Control of 4-(4-Chlorophenyl)piperidin-4-ol And the article contains the following content:
Objective- The outstanding position of piperidine analogs has proven them an important core in the structures of pharmaceutically active mols., naturally occurring alkaloids, pharmaceuticals and as synthetic intermediates with interesting biol., phys. and pharmacol. behaviors. The piperidine ring containing compound like pethidine having strong opiod analgesic activity, more potent than codein and controls the pain of smooth muscle spasm. Because of having similarity in structure the present study was aimed to estimate the analgesic activity of synthesized derivatives of 4-(4′-Chlorophenyl)-4-hydroxy piperidine. Method- The present study was conducted in animal model, mice by using Pethidine as standard drug. For which the Eddy’s hot plate method was adopted and analgesia (mean increase in latency) was observed Result- The result showed the more prominent response of substituted compound than the parent one “4-(4′-Chlorophenyl)-4-hydroxy piperidine” and it was studied that alteration in the mol. structure is accountable for a better analgesic response. Conclusion- The studies proved the pos. pharmacol. responsiveness of the combination of 4-(4′-Chlorophenyl)-4-hydroxy piperidine with phencyl halides. These synthesized derivatives will establish as potent analgesics. The experimental process involved the reaction of 4-(4-Chlorophenyl)piperidin-4-ol(cas: 39512-49-7).Quality Control of 4-(4-Chlorophenyl)piperidin-4-ol
The Article related to chlorophenyl hydroxy piperidine analgesic activity structural modification, Pharmacology: Effects Of Nervous System- and Behavior-Affecting Drugs and Neuromuscular Agents and other aspects.Quality Control of 4-(4-Chlorophenyl)piperidin-4-ol
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem