Liu, Kai; Zhang, Datong; Chojnacki, Jeremy; Du, Yuhong; Fu, Haian; Grant, Steven; Zhang, Shijun published an article in 2013, the title of the article was Design and biological characterization of hybrid compounds of curcumin and thalidomide for multiple myeloma.Application In Synthesis of 2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindoline-5-carboxylic acid And the article contains the following content:
In our efforts to develop effective treatment agents for human multiple myeloma (MM), a series of hybrid mols. based on the structures of thalidomide (I) and curcumin (II) were designed, synthesized, and biol. characterized in human multiple myeloma MM1S, RPMI8226, U266 cells, and human lung cancer A549 cells. The biol. results showed that two hybrid compounds, III and IV, exhibited significantly improved lethal effects towards all three human MM cell models compared to I or II alone, as well as the combination of I and II. Furthermore, mechanistic studies in U266 cells demonstrated that III and IV can induce the production of reactive oxygen species (ROS) and cause G1/S arrest, thus leading to apoptosis and cell death. Addnl., they exhibited inhibitory effects on NFκB activation in A549 cells. Collectively, the results obtained from these hybrid compounds strongly encourage their further optimization as new leads to develop effective treatment agents for human MM. The experimental process involved the reaction of 2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindoline-5-carboxylic acid(cas: 1216805-11-6).Application In Synthesis of 2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindoline-5-carboxylic acid
The Article related to curcumin thalidomide hybrid preparation multiple myeloma treatment, Biomolecules and Their Synthetic Analogs: Others, Including Purines, Pyrimidine Nucleic Acid Bases, Flavins, Lignans and other aspects.Application In Synthesis of 2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindoline-5-carboxylic acid
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