On August 15, 2014, Salama, Ismail; Loeber, Stefan; Huebner, Harald; Gmeiner, Peter published an article.COA of Formula: C11H14ClNO The title of the article was Synthesis and binding profile of haloperidol-based bivalent ligands targeting dopamine D2-like receptors. And the article contained the following:
Homodimers of dopamine D2-like receptors are suggested to be of particular importance in the pathophysiol. of schizophrenia and, thus, serve as promising targets for the discovery of atypical antipsychotics. This study describes the development of a series of novel bivalent mols. with a pharmacophore derived from the dopamine receptor antagonist haloperidol. These dimers were investigated in comparison to their monomeric analogs for their D2long, D2short, D3, and D4 receptor binding and the ability to bridge two neighboring receptor protomers. Radioligand binding studies provided diagnostic insights when Hill slopes close to two for the bivalent ligand 13 incorporating 22 spacer atoms and a comparative anal. with monovalent control ligands indicated a bivalent binding mode with a simultaneous occupancy of two neighboring binding sites. The experimental process involved the reaction of 4-(4-Chlorophenyl)piperidin-4-ol(cas: 39512-49-7).COA of Formula: C11H14ClNO
The Article related to preparation haloperidol bivalent ligand dopamine d2 receptor antipsychotic, binding affinity, bivalent ligands, d(2) receptor, d(3) receptor, d(4) receptor, dopamine, gpcr dimers and other aspects.COA of Formula: C11H14ClNO
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem