On September 21, 2018, Mowrey, Dale R.; Reif, James J.; Milkiewicz, Karen L.; Allwein, Shawn P. published an article.Related Products of 883984-95-0 The title of the article was Development of a Novel Process for the Kilogram-Scale Synthesis of Spiro[1H-pyrido[2,3-d][1,3]oxazine-4,4′-piperidine]-2-one. And the article contained the following:
The dihydrochloride of spiro[1H-pyrido[2,3-d][1,3]oxazine-4,4′-piperidine]-2-one I·2 HCl was prepared on kilogram scale by base-mediated Boc protection of 3-bromo-2-pyridinamine, metalation with i-PrMgCl and spirocyclization with 1-Boc-4-piperidinone, and Boc deprotection with aqueous HCl in isopropanol. A two-batch kilo lab campaign generated I·2 HCl in >99% HPLC area purity and in 77% overall yield. The experimental process involved the reaction of Benzyl 7′-chloro-2′-oxo-1′,2′-dihydrospiro[piperidine-4,4′-pyrido[2,3-d][1,3]oxazine]-1-carboxylate(cas: 883984-95-0).Related Products of 883984-95-0
The Article related to spiropyridooxazinepiperidinone kilogram scale preparation, butoxycarbonylation bromopyridinamine metalation spirocyclization butoxycarbonylpiperidone neutralization kilogram scale and other aspects.Related Products of 883984-95-0
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem