On August 25, 2016, Boudhar, Aicha; Ng, Xiao Wei; Loh, Chiew Yee; Chia, Wan Ni; Tan, Zhi Ming; Nosten, Francois; Dymock, Brian W.; Tan, Kevin S. W. published an article.Safety of 4-(4-Chlorophenyl)piperidin-4-ol The title of the article was Overcoming chloroquine resistance in malaria: Design, synthesis and structure-activity relationships of novel chemoreversal agents. And the article contained the following:
Malaria remains a significant infectious disease with even artemisinin-based therapies now facing resistance in the field. Development of new therapies is urgently needed, either by finding new compounds with unique modes of action, or by reversing resistance towards known drugs with ‘chemosensitizers’ or ‘chemoreversal’ agents (CRA). Concerning the latter, we have focused on the resistance mechanisms developed against chloroquine (CQ). We have synthesized a series of compounds related to previously identified CRAs, and found promising novel compounds These compounds show encouraging results in a coumarin labeled chloroquine uptake assay, exhibiting a dose response in resensitizing parasites to the antimalarial effects of chloroquine. Selected compounds show consistent potency across a panel of chloroquine and artemisinin sensitive and resistant parasites, and a wide therapeutic window. This data supports further study of CRAs in the treatment of malaria and, ultimately, their use in chloroquine-based combination therapies. The experimental process involved the reaction of 4-(4-Chlorophenyl)piperidin-4-ol(cas: 39512-49-7).Safety of 4-(4-Chlorophenyl)piperidin-4-ol
The Article related to structure malaria antimalarial chemoreversal preparation chloroquine resistance, antimalarial, artemisinin-resistant, chemoreversal, chemosensitiser, chloroquine, chloroquine-resistant and other aspects.Safety of 4-(4-Chlorophenyl)piperidin-4-ol
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem