Zapol’skii, Viktor A.; Bilitewski, Ursula; Kupiec, Soeren R.; Ramming, Isabell; Kaufmann, Dieter E. published an article in 2020, the title of the article was Polyhalonitrobutadienes as versatile building blocks for the biotargeted synthesis of substituted N-heterocyclic compounds.Application In Synthesis of 4-(4-Chlorophenyl)piperidin-4-ol And the article contains the following content:
Substituted nitrogen heterocycles are structural key units in many important pharmaceuticals. A new synthetic approach towards heterocyclic compounds displaying antibacterial activity against Staphylococcus aureus or cytotoxic activity has been developed. Selective synthesis of a series of 64 new N-heterocycles from the three nitrobutadienes, 2-nitroperchloro-1,3-butadiene, 4-bromotetrachloro-2-nitro-1,3-butadiene and (Z)-1,1,4-trichloro-2,4-dinitrobuta-1,3-diene, proved feasible. Their reactions of these butadienes with N-, O- and S-nucleophiles provided rapid access to push-pull substituted benzoxazolines, benzimidazolines, imidazolidines, thiazolidinones, pyrazoles, pyrimidines, pyridopyrimidines, benzoquinolines, isothiazoles, dihydroisoxazoles and thiophenes with unique substitution patterns. Antibacterial activities of the synthesized compounds were examined Seven studied compounds exhibited a significant cytotoxicity with IC50-values from 1.05 to 20.1μM. In conclusion, it was demonstrated that polyhalonitrobutadienes have an interesting potential as structural backbones for a variety of highly functionalized, pharmaceutically active heterocycles. The experimental process involved the reaction of 4-(4-Chlorophenyl)piperidin-4-ol(cas: 39512-49-7).Application In Synthesis of 4-(4-Chlorophenyl)piperidin-4-ol
The Article related to butadiene nitro polyhalo preparation heterocyclization, nitrogen heterocycle preparation antitumor antibacterial activity, heterocyclization, medicinal chemistry, nitrogen heterocycles, nucleophilic substitution, polyhalonitrobutadienes and other aspects.Application In Synthesis of 4-(4-Chlorophenyl)piperidin-4-ol
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem