On October 18, 2019, Lin, Zhiyang; Lan, Yun; Wang, Chuan published an article.Formula: C11H14ClNO The title of the article was Reductive Allylic Defluorinative Cross-Coupling Enabled by Ni/Ti Cooperative Catalysis. And the article contained the following:
Tertiary alkyl chlorides, secondary alkyl chlorides and bromides, and primary alkyl bromides underwent chemoselective defluorinative cross-coupling reactions with α-trifluoromethyl aryl alkenes in the presence of (indenyl)TiCl3, NiBr2, and 3,4,7,8-tetramethyl-1,10-phenanthroline to yield α-substituted aryl difluoroalkenes such as 4-MeOC6H4C(:CF2)CH2R (R = t-Bu, cyclohexyl, n-octyl). Unfunctionalized and ester-functionalized alkyl halides underwent cross-coupling under the reaction conditions, while a variety of functionalized aryl alkenes underwent cross-coupling. Using this method, gem-difluoroalkene analogs of azaperone, haloperidol, and benperidol were prepared The experimental process involved the reaction of 4-(4-Chlorophenyl)piperidin-4-ol(cas: 39512-49-7).Formula: C11H14ClNO
The Article related to alkyl aryl difluoroalkene chemoselective preparation, nickel titanium catalyst reductive defluorinative coupling trifluoromethylalkene chloroalkane bromoalkane, tertiary secondary chloroalkane reductive defluorinative coupling trifluoromethyl aryl alkene, secondary primary bromoalkane reductive defluorinative coupling trifluoromethyl aryl alkene and other aspects.Formula: C11H14ClNO
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem