Pediconi, Natalia’s team published research in Bioconjugate Chemistry in 2021 | CAS: 1445-73-4

1-Methyl-4-piperidone(cas: 1445-73-4) is a member of piperidine. Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Hence, continuous efforts have been made to develop convenient methods to prepare piperidine derivatives.HPLC of Formula: 1445-73-4

Pediconi, Natalia; Ghirga, Francesca; Del Plato, Cristina; Peruzzi, Giovanna; Athanassopoulos, Constantinos M.; Mori, Mattia; Crestoni, Maria Elisa; Corinti, Davide; Ugozzoli, Franco; Massera, Chiara; Arcovito, Alessandro; Botta, Bruno; Boffi, Alberto; Quaglio, Deborah; Baiocco, Paola published an article in 2021. The article was titled 《Design and Synthesis of Piperazine-Based Compounds Conjugated to Humanized Ferritin as Delivery System of siRNA in Cancer Cells》, and you may find the article in Bioconjugate Chemistry.HPLC of Formula: 1445-73-4 The information in the text is summarized as follows:

Gene expression regulation by small interfering RNA (siRNA) holds promise in treating a wide range of diseases through selective gene silencing. However, successful clin. application of nucleic acid-based therapy requires novel delivery options. Herein, to achieve efficient delivery of neg. charged siRNA duplexes, the internal cavity of “”humanized”” chimeric Archaeal ferritin (HumAfFt) was specifically decorated with novel cationic piperazine-based compounds (PAs). By coupling these rigid-rod-like amines with thiol-reactive reagents, chemoselective conjugation was efficiently afforded on topol. selected cysteine residues properly located inside HumAfFt. The capability of PAs-HumAfFt to host and deliver siRNA mols. through human transferrin receptor (TfR1), overexpressed in many cancer cells, was explored. These systems allowed siRNA delivery into HeLa, HepG2, and MCF-7 cancer cells with improved silencing effect on glyceraldehyde-3-phosphate dehydrogenase (GAPDH) gene expression with respect to traditional transfection methodologies and provided a promising TfR1-targeting system for multifunctional siRNA delivery to therapeutic applications. In the experiment, the researchers used 1-Methyl-4-piperidone(cas: 1445-73-4HPLC of Formula: 1445-73-4)

1-Methyl-4-piperidone(cas: 1445-73-4) is a member of piperidine. Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Hence, continuous efforts have been made to develop convenient methods to prepare piperidine derivatives.HPLC of Formula: 1445-73-4

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem