In 2013,Zhang, Xu; Peng, Ting; Ji, Xun; Li, Jian; Tong, Linjiang; Li, Zeng; Yang, Wei; Xu, Yungen; Li, Mengyuan; Ding, Jian; Jiang, Hualiang; Xie, Hua; Liu, Hong published 《Design, synthesis and biological evaluation of novel 4-anilinoquinazolines with C-6 urea-linked side chains as inhibitors of the epidermal growth factor receptor》.Bioorganic & Medicinal Chemistry published the findings.Recommanded Product: 622-26-4 The information in the text is summarized as follows:
A novel series of anilinoquinazoline compounds with C-6 urea-linked side chains was designed and synthesized as reversible inhibitors of epidermal growth factor receptor (EGFR) based on the structure-activity relationships (SARs) of anilinoquinazoline inhibitors. All compounds demonstrated good inhibition of EGFR wild type (EGFR wt) and inhibited proliferation of A431cell line. Compounds (I) and (II) almost completely blocked the phosphorylation of EGFR in A431 cell line at 0.01 μM. Interestingly, all of the compounds also demonstrated moderate inhibition of EGFR/T790M/L858R. In addition, compounds (III) and (IV) blocked the autophosphorylation of EGFR in NCI-H1975 cells at high concentration (10 μM), and compound 8f was confirmed to be an irreversible inhibitor through the dilution method. Importantly, the compounds with C-6 urea-linked side chains which did not contain Michael acceptors demonstrated moderate to strong irreversible EGFR inhibition. In the experimental materials used by the author, we found 2-(Piperidin-4-yl)ethanol(cas: 622-26-4Recommanded Product: 622-26-4)
2-(Piperidin-4-yl)ethanol(cas: 622-26-4) can be used to synthese ursolic acid derivatives, spiroimidazolidinone NPC1L1 inhibitors, neurokinin-2 receptor antagonists, antagonists for inhibition of platelet aggregation.Recommanded Product: 622-26-4
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem