136624-42-5, 4-Amino-1-benzylpiperidine-4-carbonitrile is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
STEP B: 4-Amino-1 -benzylpiperidine-4-carboxamide To a solution of 4-amino-1 -benzylpiperidine-4-carbonitrile (6.15 g, 28.6 mmol) in DCM (70 mL) at -5C was added 95-97% sulfuric acid (50 mL). The reaction mixture was stirred at 0 to 5C overnight and the organic layer was discarded. The resulting mixture was poured onto crushed ice (1000 mL) and the pH adjusted to pH 9 with aqueous 5N NaOH, keeping the temperature below 10C. The resulting mixture was partitioned between water and EtOAc (3 x 500 mL). The organic phase was dried over MgS04, filtered and concentrated in vacuo to yield a residue. The residue was purified by flash chromatography (silica gel, 5% MeOH in DCM) to yield 2-(4-bromophenyl)-1 ,3- diazaspiro[4.4]non-1 -en-4-one (5.06 g, 76%). 1 H NMR (300 MHz, CDCI3) delta ppm 1 .29 – 1 .57 (m, 4 H), 2.14 – 2.39 (m, 4 H), 2.71 – 2.84 (m, 2 H), 3.55 (s, 2 H), 5.41 (br. s., 1 H), 7.20 – 7.38 (m, 5 H), 7.45 (br. s., 1 H); MS m/z 234 (M+H)+.
136624-42-5, 136624-42-5 4-Amino-1-benzylpiperidine-4-carbonitrile 10680206, apiperidines compound, is more and more widely used in various fields.
Reference£º
Patent; JANSSEN PHARMACEUTICA NV; BIGNAN, Gilles C.; CONNOLLY, Peter J.; LU, Tianbao L.; PARKER, Michael H.; LUDOVICI, Donald; MEYER, Christophe; MEERPOEL, Lieven; SMANS, Karine; ROCABOY, Christian; WO2014/39769; (2014); A1;,
Piperidine – Wikipedia
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