Frolov, Andriy I.; Ostapchuk, Eugeniy N.; Pashenko, Alexander E.; Chuchvera, Yaroslav O.; Rusanov, Eduard B.; Volochnyuk, Dmitriy M.; Ryabukhin, Sergey V. published an article in 2021. The article was titled 《Selective α-Methylation of Ketones》, and you may find the article in Journal of Organic Chemistry.Reference of 1-Methyl-4-piperidone The information in the text is summarized as follows:
The convenient and scalable preparative approach for the two-step α-methylation of ketones was described. The optimized protocols for regioselective preparation of enaminones with further diastereoselective and functional groups tolerant hydrogenation to α-methylketones was developed. The scope and limitations of the proposed methodol. were discussed. The advantages compared to known procedures were demonstrated. The unexpected role of acetone in the hydrogenation was suggested. The evaluation of the method for both early building block synthesis and late-stage CH-functionalization was shown. The elaborate procedures preparability and scalability were demonstrated by the synthesis of several α-Me ketones up to 100 g amount The results came from multiple reactions, including the reaction of 1-Methyl-4-piperidone(cas: 1445-73-4Reference of 1-Methyl-4-piperidone)
1-Methyl-4-piperidone(cas: 1445-73-4) is a member of piperidine. Piperidine-containing compounds are also frequently employed in synthesis as ligands or auxiliaries. Accordingly, many efforts have been devoted to the development of novel methods for the synthesis of these compounds over the years.Reference of 1-Methyl-4-piperidone
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem