177-11-7, 1,4-Dioxa-8-azaspiro[4.5]decane is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a stirred solution of 2,6-dimethylbenzoic acid (2.5Og, 16.6mmol) in DCM (90ml) was added HOBT (2.29g, 16.6mmol), WSCDI (3.8Og, 19.9mmol), N-methylmorpholine (3.66ml, 33mmol) and 1 ,4- dioxa-8-azaspiro(4.5)decane (2.38g, 16.6mmol). This was stirred for 16h at RT and then the reaction was quenched by adding 1M aqueous sodium hydroxide solution (20ml). The organic layer was separated, dried over magnesium sulfate and then evaporated to leave an orange oil. Purification by column chromatography (silica, eluting with MeOH in DCM 0 – 2%) afforded the title compound as a colourless oil (3.6Og, 79%). LRMS: m/z APCI+276 [MH+]., 177-11-7
As the paragraph descriping shows that 177-11-7 is playing an increasingly important role.
Reference£º
Patent; PFIZER LIMITED; WO2007/116313; (2007); A2;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem